国际神经病学神经外科学杂志2013，Vol.40Issue(3)：226-230,5.
中枢神经系统原发性黑色素瘤10例临床分析
Diagnosis and treatment of primary melanoma of the central nervous system: a clinical analysis of 10 cases
朱蔚林 1黄垂学 1漆松涛 2李伟光 2彭林 2赵建农1
作者信息
- 1. 海南省人民医院神经外科,海南海口570311
- 2. 南方医科大学南方医院神经外科,广东广州510515
- 折叠
摘要
Abstract
Objective To investigate the diagnosis and treatment and follow-up results of primary melanoma of the central nervous system (CNS).Methods A retrospective analysis was performed on the clinical manifestations,radiological features,pathological findings,surgical treatment,and prognosis of 10 patients with primary melanoma of the CNS who were hospitalized from January 2002 to January 2013.Results Of the 10 cases,8 had intracranial melanoma,1 had intraspinal melanoma,and 1 had melanoma at the craniocervical junction.Total resection was achieved in 8 cases,and subtotal resection in 2 cases.The pathological examination showed that melanoma was found in 8 cases,and meningeal melanocytoma in 2 cases.During follow-up (3 months to 11 years),6 cases died,and one of them survived for 7 years after operation with comprehensive treatment and died of complications.The median survival time was 1.1 years.4 cases showed a significant recovery after surgery and a full course of radiotherapy.Conclusions Primarymelanoma of the CNS is an extremely rare tumor and radiological presentation and preoperative diagnosis could be difficult and confusing,leading to a high misdiagnosis rate.The optimal treatment for this disease is surgical resection followed by radiotherapy or chemotherapy for patients whose tumors are not totally removed.Comprehensive treatment for primary melanoma may prolong the survival period.However,the ultimate prognosis remains poor.关键词
黑色素瘤/神经系统肿瘤/诊断与治疗Key words
melanoma/nervous system neoplasm/diagnosis and treatment引用本文复制引用
朱蔚林,黄垂学,漆松涛,李伟光,彭林,赵建农..中枢神经系统原发性黑色素瘤10例临床分析[J].国际神经病学神经外科学杂志,2013,40(3):226-230,5.
