华西口腔医学杂志2013，Vol.31Issue(4)：415-419,424,6.DOI:10.7518/hxkq.2013.04.021
牙周非手术治疗对2型糖尿病伴牙周炎患者糖化血红蛋白A1c和血清可溶性细胞间黏附分子-1的影响
Effect of non-surgical periodontal therapy on level of serum soluble intercellular adhesion molecule-1 and glycated hemoglobin A1c in patients with type 2 diabetes and chronic periodontitis
摘要
Abstract
Objective To evaluate the effects of non-surgical periodontal treatment on clinical periodontal measurements,glycemic control,and level of serum soluble intercellular adhesion molecule-1 (sICAM-1) in type 2 diabetes mellitus with chronic periodontitis patients.Methods Patients with type 2 diabetes and chronic periodontitis were selected and classified into well-controlled group[glycated hemoglobin A1c(GHbA1c)＜7.00％,n=30,DMCP1 group] and poorly-controlled group (GHbA1c≥ 7.00％,n=30,DMCP2 group).Thirty systemically healthy patients with chronic periodontitis were recruited as control group (CP group),All subjects underwent non-surgical periodontal therapy.Plaque index(PLI),sulcus bleeding index (SBI),bleeding on probing(BOP),probing depth (PD),clinical attachment loss (CAL),serum sICAM-1 concentration,and the value of fasting plasma glucose(FPG),GHbA1c were recorded at baseline,1 and 3 months after periodontal treatment.Results The three study groups showed significant improvements for the levels of PD,SBI,PLI,BOP,and serum sICAM-1 concentration at 1 and 3 months after non-surgical periodontal treatment （P＜0.05).The level of CP group and DMCP1 group also showed significant improvements for the levels of CAL(P＜0.05),but no significant change was found in DMCP2 group(P＞0.05).At 3 months after periodontal treatment,GHbA1c levels in DMCP2 group significantly decreased by 1.12％（P＜0.05),whereas no significant changes were found in CP and DMCP1 groups (P＞0.05).Conclusion Non-surgical periodontal treatment can significantly improve periodontal health status in patients with type 2 diabetes and periodontitis,reduce the level of serum sICAM-1,and can reduce the level of GHbA1c in poorly controlled type 2 diabetic patients.关键词
慢性牙周炎/2型糖尿病/牙周非手术治疗/糖化血红蛋白A1c/可溶性细胞间黏附分子-1Key words
chronic periodontitis/ type 2 diabetes mellitus/ non-surgical periodontal therapy/ glycated hemoglobin A1c/ soluble intercellular adhesion molecule-1分类
医药卫生引用本文复制引用
袁堂霞,张彦表,周云,王凡涛,王峰..牙周非手术治疗对2型糖尿病伴牙周炎患者糖化血红蛋白A1c和血清可溶性细胞间黏附分子-1的影响[J].华西口腔医学杂志,2013,31(4):415-419,424,6.基金项目
潍坊市科学技术发展计划基金资助项目(20121239) （20121239）
