基础医学与临床2013，Vol.33Issue(8)：1038-1042,5.
儿童与成人弥漫大B细胞淋巴瘤的Hans、Choi免疫分型和C-MYC基因特征
Hans, Choi immunophenotyping and C-MYC genetic features between pediatric and adult diffuse large B-cell lymphoma
徐红艳 1黄慧 1杨文萍 1黄传生 2钟梅慧1
作者信息
- 1. 江西省儿童医院病理科
- 2. 江西省肿瘤医院病理科,江西南昌330006
- 折叠
摘要
Abstract
Objective To explore the difference of Hans,Choi immunophenotyping and C-MYC gene characteristics between pediatric and adult diffuse large B-cell lymphoma.Methods To collect 60 cases of DLBCL clinicopathological data and follow-up,which contained 17 cases of children group,adult group of 43 patients.To observe CD10,BCL-6,MUM1,FOXP1,GCET1 and CD5 protein expression by immunohistochemical SP method and evaluated by Hans and Choi immunophenotyping standard genotyping.To detect C-MYC gene circumstances by interphase fluorescence insituhybridization (FISH).Results 1) Hans typing:the Children DLBCL group of GCB were 11 cases,non-GCB type were 6 cases; the GCB type in the adult DLBCL group were nine cases,non-GCB type were 34 cases.2)Choi typing:the Children DLBCL group of GCB type were 13 cases,ABC type were 4 cases; the adult DLBCL group of GCB type were 13 cases,ABC type were 30 cases (P ＜ 0.01).3) C-MYC gene:The C-MYC gene disruption of children DLBCL were 5 cases; C-MYC gene in 43 adult cases were normal(P ＜0.01).Conclusions Child DLBCL of GCB-type with better prognosis while but non-GCB-type predict worse prognosis.The C-MYC gene disruption in Children DLBCL was significantly higher than that of adult ones.关键词
儿童/淋巴瘤/免疫分型/原位杂交Key words
Child/ lymphoma/ Immunophenotyping/ Insituhybridization分类
医药卫生引用本文复制引用
徐红艳,黄慧,杨文萍,黄传生,钟梅慧..儿童与成人弥漫大B细胞淋巴瘤的Hans、Choi免疫分型和C-MYC基因特征[J].基础医学与临床,2013,33(8):1038-1042,5.
