临床误诊误治2013，Vol.26Issue(7)：12-14,3.DOI:10.3969/j.issn.1002-3429.2013.07.005
严重创伤患者早期血清降钙素原水平变化对预后评估的意义
The Prognosis Value of Change Levels of Serum Procalcitonin in Early Stage on Patients with Severe Trauma
摘要
Abstract
Objective To explore levels of serum procalcitonin (PCT) in patients with severe trauma in evaluation of clinical significances of prognosis.Methods Levels of serum PCT in 93 patients with systemic inflammatory response syndrome (SIRS)after severe trauma were detected at 1 st d,2nd d and 3rd d before admission,and the division of groups was based on changes of the levels of serum PCT.Survival rates,times of mechanical ventilation,length of stay in ICU,and the correlation between PCT levels and scores of severe trauma levels at 28th d after admission were evaluated.Results Among 93 patients,83 patients survived (survival group) and 10 patients died (mortality group) at 28th d after admission.Levels of serum PCT at the 3 d before admission in mortality group were significantly higher than those in survival group (P ＜ 0.05),and the trend rose higher and higher (P ＜ 0.05) ;the differences in length of stay in ICU and times of mechanical ventilation between mortality group and survival group were statistically significant (P ＜ 0.05).All the patients in normal group (n =10) and low level group (n =26) survived,1 patient (2.17％)died in middle level group (n =46),9 patients (81.82％) died in high level group (n =11),the mortality rate in high level group was significantly higher than those in other groups (P ＜ 0.05).With PCT levels increased,times of mechanical ventilation,length of stay in ICU,and scores of severe trauma levels were significantly increased (P ＜ 0.05).Spearman correlative analysis shows that PCT level was correlated with APACHE Ⅱ and ISS scores (P ＜ 0.05).Conclusion As a marker to evaluate the prognosis the level of serum PCT is connected with prognosis of patients with severe trauma.关键词
创伤/全身炎症反应综合征/降钙素原Key words
Trauma/ Systemic inflammatory response syndrome/ Procalcitonin分类
医药卫生引用本文复制引用
杨兴伟,董士民..严重创伤患者早期血清降钙素原水平变化对预后评估的意义[J].临床误诊误治,2013,26(7):12-14,3.基金项目
国家自然科学基金(编号:81070122) （编号:81070122）
