临床误诊误治2013，Vol.26Issue(7)：83-85,3.DOI:10.3969/j.issn.1002-3429.2013.07.035
塞来昔布联合奥施康定治疗中重度癌痛的临床观察
Clinical Observation of Cyclooxygenase-2 Inhibitor Celecoxib Combined with Oxycontin in Treatment of Moderate and Severe Cancer Pain
摘要
Abstract
Objective To observe curative effect and safety of Celecoxib combined with Oxycontin in treatment of moderate and severe cancer pain.Methods A total of 55 hospitalized patients with cancer of moderate and severe cancer pain,clear consciousness during May 2011 and January 2013 were recruited in this study.Patients without tolerance of opium were treated with Oxycontin at an initial dose of 10mg and 1 time of every 12 h ; patients with tolerance of opium were treated with Oxycontin at an initial dose of 10mg and once every 12 h for moderate cancer pain,and Oxycontin at an initial dose of 20mg and once every 12 h for severe cancer pain.A total of 200mg of celecoxib was given every 12 h at the same time.Results The pain remission rate and quality of life were evaluated after medication for 4 weeks.In the 55 patients,there were 1 patient (1.82) without remission,4 (7.27％)with slight remission,13 (23.64％) with moderate remission,26 (47.27％) with obvious remission and 11 (20.00％) with complete remission.The pain remission rate was 90.91％.The KPS function score improved significantly,and the difference was statistically significant between that before treatment and that after treatment (P ＜0.05).The common adverse reactions were constipation,nauseated,vomiting,dizziness,somnolence and dysuria,and there was no serious adverse drug reaction.Conclusion Celecoxib combined with Oxycontin in treatment of moderate and severe cancer pain may have obvious efficiency,with a better rate of pain remission and improvement of quality of life.关键词
塞来昔布/奥施康定/癌痛/疗效/不良反应/生活质量Key words
Celecoxib/Oxycontin/Cancer pain/ Curative effect/ Adverse reaction/ Quality of life分类
医药卫生引用本文复制引用
雷俊华,洪涛,曾江正..塞来昔布联合奥施康定治疗中重度癌痛的临床观察[J].临床误诊误治,2013,26(7):83-85,3.基金项目
海南省重点项目(ZDXM 20100046) （ZDXM 20100046）
