摘要
Abstract
Objective:To investigate the effects of Qilian Zengmin Prescription on insulin sensitivity,plasma hs-CRP,IL-6 and TNF-α in patients with impaired glucose tolerance (IGT).Methods:Sixty patients with IGT were randomly assigned to the controlled (n=30) and Chinese medicine (n=30) groups.The former was given diet and exercise therapy,while the latter was received diet and exercise therapy,and Qilian Zengmin Prescription.The course lasted one month.Before and after treatment,fasting plasma glucose (FBG),2 hour postprandial glucose (2hPBG),fasting insulin (FINS),and 2 hour postprandial insulin (2h PINS) were checked.Insulin sensitivity was evaluated by HOMA insulin resistance (HOMA-IR).Plasma hs-CRP was measured by immune turbidity method,and enzyme linked immunosorbent assay was used to analyze IL-6 and TNF-α.Results:After treatment,the levels of FBG,2hPBG,FINS,2hPINS and HOMA-IR in Chinese medicine group were all significantly decreased when compared to before treatment (all P＜0.01),and HOMA-IR in Chinese medicine group after treatment was much lower than that in the controlled group (P＜0.05).Furthermore,compared to before treatment,the levels of hsCRP,IL-6 and TNF-α in Chinese medicine groupafter treatment were all markedly decreased (all P＜0.01),and also much lower than that in the controlled group (P＜0.05 or P＜0.01).Conclusions:Qilian Zengmin Prescription improves insulin sensitivity in patients with impaired glucose tolerance,which has close relationship with the decreases in hs-CRP,IL-6 and TNF-α.关键词
糖耐量减退/胰岛素抵抗/hs-CRP/IL-6/TNF-αKey words
Impaired glucose tolerance/ Insulin resistance/ hs-CRP/ IL-6/ TNF-α分类
医药卫生
