四川中医2013，Vol.31Issue(7)：61-64,4.
中西医结合治疗肝衰竭的疗效评价
Curative Effect Evaluation of Integrated Traditional Chinese Medicine and Western Medicine on Treating Liver Failure
摘要
Abstract
Objective:To evaluate the curative effect of Traditional Chinese Medicine on the basis of western medicine together with nonbioartificial liver treatment for liver failure.Methods:Using the prospective,randomized controlled research.Cases of liver failure who would integrate the elimination standard along with the enroll standard,stochastically entered the controlled group (western medicine together with nonbioartificial liver) and the treatment group (Traditional Chinese Medicine on the basis of western medicine together with nonbioartificial liver).To analyze the differences of mortality rate,survival time,incidence of complications,biochemical and coagulation parameters to improve at different time node in two groups.Results:1)At baseline,sex,age,disease duration,family history,etiology,pathogen type,type and stage of liver failure,incidence of complications,biochemical parameters,blood coagulation parameters and virological indicators were similar to each other in two groups.So at baseline it has comparability in two groups.2) The mortality rate in the treatment group was significantly lower than that in the control group (7.69％ VS 25.00％,P =0.087) at the end of four weeks.3) Incidence of primary peritonitis in the treatment group was significantly lower than that in the controlled group (15.38％ VS 43.75％,P=0.021).Incidence of hepatic encephalopathy,hepatorenal syndrome,gastrointestinal bleeding and electrolyte disturbance in the treatment group was a little lower than that in the controlled group.4) Total bilirubin in the treatment group was significantly lower than that in the controlled group from first week to the end of four weeks (198.63 VS 235.32,133.28 VS 220.93,83.58 VS 154.08,67.38 VS 92.58,P=0.306,0.014,0.012,0.203 respectively),especially at the end of two and three weeks.In the treatment group alanine aminotransferase,aspartate transaminase were a little lower and serum albumin,prothrombin activity were a little higher than that in the controlled group from first week to the end of three weeks.Conclusions:Traditional Chinese Medicine on the basis of western medicine together with nonbioartificial liver can improve liver failure patients liver function and coagulation function,reduce mortality rate and decrease Incidence of complications at the end of four weeks.关键词
肝衰竭/中医治疗/西医综合治疗/人工肝治疗/疗效Key words
Liver failure/ Traditional Chinese Medicine treatment/ Western medicine treatment/ Nonbioartificial liver treatment / Curative effect分类
医药卫生引用本文复制引用
陈定潜,曾义岚,胡蓉,王林,王丽,刘大凤,叶庆,李继科,高峰..中西医结合治疗肝衰竭的疗效评价[J].四川中医,2013,31(7):61-64,4.基金项目
四川省中医药管理局2012～2013年度专项经费资助(编号:20122A-09) （编号:20122A-09）
