山西医科大学学报2013，Vol.44Issue(7)：515-518,587,5.DOI:10.3969/J.ISSN.1007-6611.2013.07.003
线粒体DNA的ND-1基因G3316A、T3394C与老年2型糖尿病的相关性
Correlation of G3316A and T3394C mutation in the mitochondrial DNA ND-1 gene with type 2 diabetes mellitus in aged patients
许敬平 1吴大为 2邵俊涛 3李小丽4
作者信息
- 1. 河北省秦皇岛市第一医院老年病一科,秦皇岛066000
- 2. 河北港口集团港口医院肿瘤科
- 3. 河北省秦皇岛市第一医院超声科
- 4. 河北省秦皇岛市第一医院康复科
- 折叠
摘要
Abstract
Objective To explore the correlation between G3316A,T3394C mutation in the mitochondrial DNA ND-1 gene and type 2 diabetes mellitus(T2DM) in elderly patients.Methods PCR-gene sequencing technology was used to detect G3316A,T3394C mutation in 96 elderly patients with T2DM (diabetic group) and 100 elderly healthy controls with normal glucose tolerance(normal control group).Results G3316A mutation was detected in 4 cases(4.17％) of T2DM and one case(1.04％) in controls,and there was significant difference between two groups (P ＜ 0.05).T3394C mutation was detected in 3 cases (3.13％) of T2DM and one case (1.04％) in controls,and there was significant difference between two groups (P ＜ 0.05).No cross mutation of G3316A and T3394C was found.Conclusion The mutation of G3316A and T3394C in the mitochondrial DNA ND-1 gene could be related to the occurrence of T2DM in the elderly.关键词
线粒体DNA/基因突变/老年/2型糖尿病Key words
mitochondrial DNA/ gene mutation/ aged/ type 2 diabetes mellitus分类
医药卫生引用本文复制引用
许敬平,吴大为,邵俊涛,李小丽..线粒体DNA的ND-1基因G3316A、T3394C与老年2型糖尿病的相关性[J].山西医科大学学报,2013,44(7):515-518,587,5.
