山西医科大学学报2013，Vol.44Issue(7)：547-550,4.DOI:10.3969/J.ISSN.1007-6611.2013.07.011
慢性阻塞性肺疾病急性加重患者MCP-1、TF水平及临床意义
Expression and clinical significance of serum monocyte chemoattractant protein-1, tissue factor in patients with acute exacerbations of chronic obstructive pulmonary disease
王勇 1丁宁 1翟艳苓 2刘复强 2郑毅1
作者信息
- 1. 首都医科大学附属北京同仁医院急诊科,北京100730
- 2. 首都医科大学附属北京同仁医院血液科
- 折叠
摘要
Abstract
Objective To investigate the changes and clinical significance of monocyte chemoattractant protein-1 (MCP-1) and tissue factor (TF) in patients with acute exacerbations of chronic obstructive pulmonary disease.Methods Forty-nine patients with AECOPD and 30 healthy controls were enrolled in this study.ELISA was used to detect plasma TF,MCP-1 and procalcitonin(PCT).AECOPD group was subgrouped into PCT increase group(n =19) and normal PCT group (n =30).Results TF,MCP-1 in AECOPD group were significantly higher than in healthy control group (P ＜ 0.01).There was a linear positive correlation between TF and MCP-1 in AECOPD patients.The levels of TF and MCP-1 were higher in PCT＞0.5 μg/L group than that in PCT ＜0.5 μg/L group (P ＜0.05).Conclusion High condensation state is activated in AECOPD patients,especially in the patients with PCT increase.To monitor the plasma TF and MCP-1 levels are important for AECOPD patients with hypercoagulability state to prevent their cardiovascular and cerebrovascular thrombotic diseases.关键词
慢性阻塞性肺疾病/组织因子/单核细胞趋化蛋白-1Key words
chronic obstructive pulmonary disease/ tissue factor/ monocyte chemoattractant protein-1分类
医药卫生引用本文复制引用
王勇,丁宁,翟艳苓,刘复强,郑毅..慢性阻塞性肺疾病急性加重患者MCP-1、TF水平及临床意义[J].山西医科大学学报,2013,44(7):547-550,4.
