山西医科大学学报2013，Vol.44Issue(7)：557-561,589,6.DOI:10.3969/J.ISSN.1007-6611.2013.07.014
双时相99Tcm-MDP断层显像在乳腺疾患中的应用
Application of dual-phase tomographic imaging with 99Tcm-MDP in diagnosis of breast diseases
摘要
Abstract
Objective To explore the clinical diagnostic value of dual-phase 99Tcm-MDP tomography for breast diseases.Methods Fifty female healthy volunteers and 68 female patients with breast diseases received double-phase 99Tcm-MDP tomography in this study.Radioactive counts and target/non-target(T/NT) ratio in ROI of two sides of breasts in healthy volunteers and patients with breast diseases were calculated in early phase and delayed phase respectively,and these results were compared with surgery or biopsy pathology.Results ①T/NT ratio in benign breast lesions was 2.15 ± 0.40 and 1.10 ± 0.30 in early and delayed phases respectively (P ＜ 0.05).T/NT ratio in breast cancers was 4.51 ± 0.30 and 3.49 ± 0.40 in early and delayed phases respectively (P ＞ 0.05).T/NT ratio in early phase was significantly different among normal controls,benign breast lesions and breast cancers (P ＜ 0.05).T/NT ratio in delayed phase had significant difference between breast cancers and normal controls or benign breast lesions (P ＜ 0.05).②The overall sensitivity and specificity of dual-phase 99 Tcm-MDP tomography in diagnosis of breast cancers were 91.7％ and 93.8 ％ respectively,the accuracy was 92.7％,and the positive and negative predictive values were respectively 94.3％ and 90.9％.Conclusion The dualphase 99Tcm-MDP tomography is a more sensitive and specific imaging method in the diagnosis of breast diseases,and plays a role in the differential diagnosis of benign breast lesions and breast cancers.关键词
乳腺癌/锝标记亚甲基二膦酸盐/断层显像/T/NT比值Key words
breast cancer/ 99Tcm methylene diphosphonate/ tomography/ target/non-target ratio分类
医药卫生引用本文复制引用
张胜潮,高润芳,冯贵生,徐成..双时相99Tcm-MDP断层显像在乳腺疾患中的应用[J].山西医科大学学报,2013,44(7):557-561,589,6.基金项目
卫生厅科技攻关基金资助项目(200819) （200819）
