实用医学杂志2013，Vol.29Issue(13)：2094-2096,3.DOI:10.3969/j.issn.1006-5725.2013.13.010
嗅球部多巴胺能神经元在帕金森病并发嗅觉障碍中的作用
Role of olfactory bulb dopamine neurons in olfactory dysfunction in Parkinson's disease
王春华 1陈祥 1于洋 2高殿帅 3肖成华4
作者信息
- 1. 224400 江苏省盐城市阜宁县人民医院
- 2. 224600 江苏省盐城市响水县人民医院
- 3. 221000 徐州医学院神经生物学教研室
- 4. 221000 徐州医学院神经病学教研室
- 折叠
摘要
Abstract
Objective To investigate the role of olfactory bulb dopamine (DA) neurons in olfactory dysfunction in Parkinson's disease.Methods C57BL/6 mice were treated with 1-methyl-4-phenyl-1,2,3,6-tetrapyridine (MPTP) of 25 mg/kg twice a week for 5 weeks; and were assigned to a group of olfactory dysfunction complicated by Parkinson's disease and a control group based on the result of buried food pellet test.Another group received injections of normal sodium as NS group.The number of tyrosine hydroxylase (TH)-positive cells in olfactory bulb was determined by immunohistochemistry and TH proteins were detected by Western blot.Results As compared with the control group,the number of TH-positive cells and TH proteins in olfactory bulb in the group of olfactory dysfunction in Parkinson's disease were decreased with a significant difference (P ＜ 0.05); and as compared with NS group,the number of TH-positive cells and TH proteins in olfactory bulb were also decreased in control group with a significant difference (P ＜ 0.05).Conclusions Olfactory dysfunction in Parkinson's disease may be related to a decrease in the number of olfactory bulb DA neurons.关键词
嗅觉障碍/帕金森病/MPTP/多巴胺Key words
Olfaction disorders/ Parkinson's disease/ MPTP/ Dopamine引用本文复制引用
王春华,陈祥,于洋,高殿帅,肖成华..嗅球部多巴胺能神经元在帕金森病并发嗅觉障碍中的作用[J].实用医学杂志,2013,29(13):2094-2096,3.
