实用医学杂志2013，Vol.29Issue(13)：2113-2116,4.DOI:10.3969/j.issn.1006-5725.2013.13.016
PTEN基因ⅣS4多态性与脂代谢紊乱的关系
Association of PTEN Ⅳ S4 polymorphisms with lipid metabolism disorder
摘要
Abstract
Objective To investigate the association of PTEN gene Ⅳ S4 polymorphisms with lipid metabolism disorder in the Han people who lives in southern Sichuan areas.Methods PTEN gene Ⅳ S4polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)and DNA sequencing in 431 samples (208 from patients with dyslipidemia and 223 from control subjects).Results The frequencies of Ⅳ S4 genotypes (-/-,-/+,and +/+) differed statistically between the control subjects and patients with lipid metabolism disorder (P =0.039).As compared with ⅣS4 genotypes-/-and-/+and allele (+),genotype +/+ and allele (-) had an increased risk of lipid metabolism disorder [OR:1.768,95％CI:1.135～2.753,P =0.011] and [OR:1.480,95％CI:1.135 ～ 1.929,P =0.004).In addition,levels of TC and LDL-C were markedly higher in ⅣS4 genotype +/+ than genotypes-/-and-/+ (t =-2.349,P =0.020 and t =-2.767,P =0.006).Conclusions PTEN Ⅳ S4 genotype +/+ and allele (+) are the risk factor of lipid metabolism disorder in southern Sichuan areas,which is mainly associated with TC and LDL-C.关键词
多态性,单核苷酸/PTEN基因ⅣS4多态性/脂代谢紊乱Key words
Polymorphism, single nucleotide/ PTEN gene ⅣS4 polymorphisms/ Lipid abnormalities引用本文复制引用
唐小平,周莹,赵春妮,万沁,陈枫,赖小宇,周海燕,陈庄..PTEN基因ⅣS4多态性与脂代谢紊乱的关系[J].实用医学杂志,2013,29(13):2113-2116,4.基金项目
四川省卫生厅科研课题(编号:120348) （编号:120348）
