生殖医学杂志2013，Vol.22Issue(7)：481-485,5.DOI:10.3969/j.issn.1004-3845.2013.07.003
代谢综合征与子宫内膜病变的相关性研究
Association between metabolic syndrome and endometrial disorders
摘要
Abstract
Objective..To study the association between metabolic syndrome(MS)and endometrial disorders.Methods:A total of 125 patients with abnormal uterine bleeding were divided into two groups after diagnostic curettage:metabolic syndrome group (group A,n =60) and non metabolic syndrome group (group B,n =65).The risk factors were retrospectively analyzed according to the results of endometrial pathology,which included body mass index(BMI),waist circumference(WC),hypertension,levels of sexual hormones (FSH,LH,E2,T),triglycerides (TG),high-density lipoprotein (HDL),fasting plasma glucose,fasting insulin and homeostasis model assessment of insulin resistance(HOMA-IR)between the two groups.Results:The abnormal endometrium rate including endometrial polyps,hyperplasia and carcinoma in group A was significantly higher than that in group B(P＜0.05).The BMI,WC,levels of T,fasting plasma glucose,fasting insulin,TG,and HOMA-IR and the hypertension rate in group A were significantly higher than those in group B(P＜0.05),while the HDL level in A group was significantly lower than that in group B(P＜0.05).The levels of FSH,LH and E2 in group A were slightly higher than those in group B,but there were no significant changes(P＞0.05).Conclusions:Metabolic syndrome is significantly associated with endometrial polyps,hyperplasia and carcinoma.The persistent and long-term estrogen stimulation,hyperandrogenism,insulin resistance and hyperinsulinism are the important factors for the endometrial pathological changes.Therefore,early clinical intervention should be performed in the patients with metabolic syndrom,so that the incidence of endometrial disorders can be decreased.关键词
代谢综合征X/子宫内膜病变/胰岛素抵抗Key words
Metabolic syndrome/ Endometrial disorders/ Insulin resistanc引用本文复制引用
易红,李晓红,李瑾..代谢综合征与子宫内膜病变的相关性研究[J].生殖医学杂志,2013,22(7):481-485,5.基金项目
深圳市宝安区级科技项目(20110611) （20110611）
