生殖医学杂志2013，Vol.22Issue(7)：514-516,3.DOI:10.3969/j.issn.1004-3845.2013.07.010
人乳头瘤病毒E6/E7 mRNA检测联合宫颈活检在宫颈病变中的应用价值
Application value of human papilloma virus E6/E7 mRNA detection combined with cervical biopsy in diagnosis of cervical intraepithelial neoplasia
董立军 1宋国军2
作者信息
- 1. 包头医学院第二附属医院妇产科,包头014030
- 2. 包头医学院第二附属医院核磁共振,包头014030
- 折叠
摘要
Abstract
Objective:To research the diagnosis value by determining high risk human papilloma virus(HPV) E6/E7 mRNA combined with cervical biopsy in the sample with cervical intraepithelial neoplasia after detected by liquid based thin-prep cytology test(TCT).Methods..The high risk HPV E6/E7 mRNA was detected in 100 TCT samples with different degrees of cervical lesions.The cervical biopsy examination was done for all the patients with positive or negative of HPV E6/E7 mRNA test.The correlation between the expression of HPV E6/E7 mRNA and the cytological grades was analyzed.Results:The copy number of HPV E6/E7 rnRNA was statistically different in various cytological grades (P＜0.05).The copy number of HPV E6/E7 rmRNA was correlated with severe degree of epithelial cervical dysplasia.The copy number of HPV E6/E7 rmRNA was positively correlated with positive rate of cervical biopsy.Conclusions:High risk HPV E6/E7 mRNA test combined with cervical biopsy is of clinical value for diagnosis of cervical intraepithelial neoplasia.关键词
人乳头瘤病毒/mRNA/新柏超薄液基细胞学检查/E6/E7/宫颈活检Key words
Human papilloma virus/ mRNA/ TCT/ E6/E7/ Cervical biopsy引用本文复制引用
董立军,宋国军..人乳头瘤病毒E6/E7 mRNA检测联合宫颈活检在宫颈病变中的应用价值[J].生殖医学杂志,2013,22(7):514-516,3.
