生殖医学杂志2013，Vol.22Issue(7)：551-554,4.DOI:10.3969/j.issn.1004-3845.2013.07.020
卵巢功能早衰与脆性X智力低下1基因的关系
Relationship between premature ovarian failure and fragile X mental retardation gene 1
叶玉琴 1吴洁1
作者信息
- 1. 生殖医学国家重点实验室,南京医科大学附属第一医院妇产科,南京210029
- 折叠
摘要
Abstract
Premature ovarian failure(POF)is a reproductive endocrine syndrome characterized by loss of ovarian function before the age of 40 years,with elevated follicular stimulating hormone(FSH)＞40IU/L and/or decreased levels of estrogen.Environmental factors,genetic background,autoimmunity,metabolism and iatrogenic factors are proposed to contribute to POF.However,the exact etiology of most of POF remains unknown.Some studies reported that expansion of the CGG repeats of 5'-untranslated region in the X-linked fragile X mental retardation 1 (FMR1)gene to the permutation range(55-200 repeats)was associated with pathogenesis of POF.In this review,we analyze the structure and function of the FMR1 gene in order to find the potential association between POF and FMR1 gene CGG repeat number.关键词
卵巢早衰/脆性X智力低下1基因/生殖健康Key words
Premature ovarian failure/ Fragile X mental retardation 1 (FMR1)gene/ Reproductive health引用本文复制引用
叶玉琴,吴洁..卵巢功能早衰与脆性X智力低下1基因的关系[J].生殖医学杂志,2013,22(7):551-554,4.
