畜牧兽医学报2013，Vol.44Issue(7)：993-999,7.DOI:10.11843/j.issn.0366-6964.2013.07.001
低氧适应的线粒体调控机制研究进展
HOW Mitochondria Play a Role in Hypoxic Adaptation
摘要
Abstract
O2 is essential to animals,and animal's survival is threatened when cells are deprived of O2.Eukaryotic cells respond to low-oxygen concentrations by upregulating hypoxic genes.Mitochondria have long been considered as a likely site of oxygen sensing,and mitochondrial respiratory chain is required for hypoxic signaling,though its underlying role in this process has been unclear.Mitochondria may regulate the ROS produced by respiratory chain to control the enzyme activity of PHD,or sense oxygen through the protein tyrosine nitration reaction which is the combined effect of both ROS and NO produced by mitochondria.The mtDNA mutations,cell metabolism pathway changes and respiratory chain efficiency regulations also play important roles in adaptation to hypoxia.How mitochondria play a key role in hypoxic adaptation will be reviewed,hoping more attention will be caught on the research of hypoxic adaptation and mitochondria.关键词
线粒体/低氧/呼吸链/氧感受器/ROS/NOKey words
mitochondria/ hypoxic/ respiratory chain/ O2 sensor/ ROS/ NO分类
生物科学引用本文复制引用
左清清,姚娜,董坤哲,叶绍辉,马月辉..低氧适应的线粒体调控机制研究进展[J].畜牧兽医学报,2013,44(7):993-999,7.基金项目
国家自然科学基金(31272403) （31272403）
国家绒毛用羊产业技术体系(CARS-40-01) （CARS-40-01）
