中国当代儿科杂志2013，Vol.15Issue(7)：541-545,5.DOI:10.7499/j.issn.1008-8830.2013.07.009
中性粒细胞明胶酶相关脂质转运蛋白在儿童原发性肾病综合征尿液中的表达及意义
Expression of urinary neutrophil gelatinase-associated lipocalin and its clinical significance in children with idiopathic nephrotic syndrome
夏华 1何庆南 1李晓燕 1帅兰军 1陈海霞 1易著文1
作者信息
- 1. 中南大学湘雅二医院儿童医学中心,湖南长沙410011
- 折叠
摘要
Abstract
Objective To investigate the urinary neutrophil gelatinase-associated lipocalin (NGAL) concentration in children with idiopathic nephrotic syndrome (INS) and its clinical significance.Methods Thirty-four children newly diagnosed with INS received oral prednisone for 4 weeks.Patients whose urinary protein did not become negative were classified as steroid-resistant nephrotic syndrome (SRNS) group,while those whose urinary protein did become negative were classified as steroid-sensitive nephrotic syndrome (SSNS) group.Morning midstream urine specimens were collected from all patients before use of prednisone and after 1,2,3,and 4 weeks of treatment with prednisone.Enzyme-linked immunosorbent assay was used to measure the urinary NGAL concentration.Meanwhile,urinary creatinine (Cr) concentration was measured,and urinary NGAL concentration in a single urine collection was adjusted according to the urinary Cr excretion.The two groups were compared in terms of urinary NGAL/Cr ratio.Results Compared with the SRNS group,the SSNS group had significantly decreased urinary NGAL/Cr ratios after 3 and 4 weeks of prednisone treatment (P ＜0.05).Compared with the SRNS group,the SSNS group had a significantly decreased urinary β2-MG/Cr ratio after 4 weeks of prednisone treatment (P ＜0.05).In both groups,urinary NGAL/Cr ratio was positively correlated with urinary protein/Cr ratio (r =0.510,P＜0.01).The results of ROC curve analysis showed when diagnostic cut-off point of urinary NGAL/Cr was 0.043 by 3 weeks after treatment,sensitivity and specificity achieved 100％ and 79.2％ respectively.Conclusions Urinary NGAL/Cr ratio remains high in children with SRNS,while this ratio decreases gradually during prednisone treatment in children with SSNS,and it falls ahead of urinary β2-MG/Cr ratio.These results suggest that dynamic monitoring of urinary NGAL/Cr ratio is useful for early judgment of response to prednisone in patients with INS.关键词
中性粒细胞明胶酶相关脂质转运蛋白/原发性肾病综合征/激素敏感型肾病综合征/激素耐药型肾病综合征/儿童Key words
Neutrophil gelatinase-associated lipocalin/ Idiopathic nephrotic syndrome/ Steroid-sensitive nephrotic syndrome/ Steroid-resistant nephrotic syndrome/ Child引用本文复制引用
夏华,何庆南,李晓燕,帅兰军,陈海霞,易著文..中性粒细胞明胶酶相关脂质转运蛋白在儿童原发性肾病综合征尿液中的表达及意义[J].中国当代儿科杂志,2013,15(7):541-545,5.
