摘要
Abstract
Objective To evaluate the significance of procalcitonin(PCT) test in guiding antimicrobial therapy in patients with liver cirrhosis ascites.Methods One hundred patients with liver cirrhosis ascites in a hospital between January 2009 and January 2012 were randomly divided into routine therapy group(routine comprehensive therapy,n=20) and anti-infective therapy group(cefotaxime therapy in addition to routine therapy,n =80),then anti-infective group was subdivided into anti-infective group A(PCT＜0.5 ng/mL),anti-infective group B(0.5 ng/mL≤PCT ≤2 ng/mL)and anti-infective group C(PCT＞2 ng/mL).Liver function,prothrombin activity (PTA)and therapeutic efficacy between three groups were compared.Results After therapy,the difference in serum alanine transaminase(ALT),aspartic transaminase(AST),total bilirubin(TBIL),and PTA between anti-infective group A and routine therapy group were not significantly different(all P＞0.05) ;compared with anti-infective group A and routine therapy group,ALT,AST and TBIL in anti-infective group B and C decreased significantly,while PTA increased significantly (all P＜0.05).The total efficacy rate in routine therapy group,anti-infective group A,B and C was 60.00％ (12/20),66.67％ (18/27),87.50％ (28/32),and 90.48％ (19/21),respectively(x2-9.04,P-0.03),the total efficacy rate in anti-infective group B and C increased significantly.Conclusion Detection of PCT is benefit to judge the development of bacterial peritonitis in patients with liver cirrhosis ascites and guide rational use of antimicrobial agents.关键词
降钙素原/肝硬化/腹腔积液/抗感染治疗Key words
procalcitonin/ liver cirrhosis/ ascites/ anti-infective therapy分类
医药卫生
