中国骨伤2013，Vol.26Issue(7)：613-616,4.DOI:10.3969/j.issn.1003-0034.2013.07.021
Wnt/β-catenin信号通路调节软骨代谢作用于骨坏死疾病的研究进展
Progress on Wnt/β-catenin signal pathway regulating the cartilage metabolism in osteonecrosis
摘要
Abstract
More and more scholars agreed with the viewpoint that osteonecrosis relates with the metabolic activity of chondrocyte.Moreover,the activation of β-catenin among Wnt/β-catenin signal pathway can promote differentiation of chondrocyte and can promote differentiated cell death.So it suggests that this signal pathway should have an effect to occurrence and development of osteonecrosis by regulating the metabolic activity of chondrocyte.Through the establishment of conditional β-catenin knockout mice,it is helpful to understand the pathogenesis of Wnt/β-catenin signal pathway regulating cartilage metabolism.By the way we can understand the pathogenesis of osteonecrosis and give a targeted treatment to the disease.This article reviewed the relationship of three aspects of Wnt/β-catenin signal pathway,cartilage metabolism and osteonecrosis.关键词
软骨细胞/代谢/骨坏死/Wnt/β-catenin信号通路/综述文献Key words
Chondrocytes / Metabolism / Osteonecrosis / Wnt/β-catenin signal pathway/ Review literature引用本文复制引用
谢健,童培建,肖鲁伟..Wnt/β-catenin信号通路调节软骨代谢作用于骨坏死疾病的研究进展[J].中国骨伤,2013,26(7):613-616,4.基金项目
浙江省自然基金(编号:LZ12H27001) （编号:LZ12H27001）
National Natural Science Foundation (No.LZ12H27001) （No.LZ12H27001）
