中国临床医学2013，Vol.20Issue(3)：289-291,3.
糖代谢异常对急性冠脉综合征患者远期预后的影响
Influence of Abnormal Glycometabolism on Long-Term Prognosis in Patients with Acute Coronary Syndrome
摘要
Abstract
Objective:To investigate the influence of abnormal glycometabolism on long-term prognosis of patients with acute coronary syndrome (ACS).Methods:A total of 453 patients with ACS from January 2007 to June 2010 were divided into 4 groups according to history of diabetes mellitus and results of oral glucose tolerance test (OGTT):normal plasma glucose group (132 cases),impaired fasting glucose (IFG) group (81 cases),impaired glucose tolerance (IGT) group (89 cases),and diabetes mellitus (DM) group (151 cases).All of them have been followedup by phone or clinical interview periodically for long term prognosis of patients,including major adverse cardiac events (MACE) of myocardial infarction,revascula-rization and death,etc.Results:Compared with normal plasma glucose group,the non-event median survival time in IGT and DM group were significantly shortened (both P＜0.05).However,no statistical significance was found between IFG group and normal plasma glucose group (P＞0.05).Compared with normal plasma glucose group(27.27 ％),the incidences of MACE were significantly higher in IGT group and DM group (44.94％,49.01 ％,both P ＜0.05),but no statistical significance was found between IFG group and normal plasma glucose group (32.10％,P＞0.05).Cox regression analysis showed that male,age,smoking,dyslipidemia,abnormal glycometabolism and revascularization were independent risk factors for the occurrence of MACE.Conclusions:ACS patients with IGT or DM have poorer long-term prognosis than whom with normal plasma glucose and need to be monitored by OGTT periodically.关键词
急性冠脉综合征/空腹血糖受损/糖耐量受损/远期预后Key words
Acute coronary syndrome/Impaired fasting glucose/Impaired glucose tolerance/Long-term prognosis分类
医药卫生引用本文复制引用
叶永刚,蒋利,徐颖杰,岳静雯,朱频..糖代谢异常对急性冠脉综合征患者远期预后的影响[J].中国临床医学,2013,20(3):289-291,3.基金项目
上海市卫生局科技发展基金资助(编号:054111) （编号:054111）
