中国临床药学杂志2013，Vol.22Issue(4)：226-229,4.
膀胱过度活动症治疗中安慰剂效应的影响因素分析
Analysis on influencing factors of the placebo response in overactive bladder
刘洪奕 1邹琛 2力弘 1何兵2
作者信息
- 1. 复旦大学药学院药理学教研室,上海201203
- 2. 辉瑞(中国)研究开发有限公司,上海201203
- 折叠
摘要
Abstract
AIM To study the influencing factors of the placebo response in overactive bladder (OAB).METHODS Data for analysis came from the placebo group of a completed phased 3,parallel,randomized,double-blind,placebo-controlled multicenter clinical trial which aimed at investigating the efficacy of OAB drug.Treatment response was taken as the dependent variable.Independent variables included demographic data,risk factors of OAB and OAB disease data.Variables of statistically significance found by the univariate logistic regression would be taken into the multivariate logistic regression.RESULTS The univariate logistic regression showed that 6 variables had statistical significance(P ＜ 0.1).They were consumption of caffeine,duration of OAB,severity of urinary urgency,severity of OAB,prior OAB treatment and occurrence of adverse events.The multivariate logistic regression further showed that patients with mild to moderate OAB disease were more likely to have stronger placebo response and patients who did not consume caffeine were more likely to have stronger placebo response than patients who did consume caffeine.The odds ratio(95 ％confidence interval) was 3.094(1.348-7.099) and 3.047(1.623-5.719),respectively.CONCLUSION Severity of OAB and consumption of caffeine are the independent influencing factors of the placebo response in OAB.关键词
膀胱过度活动症/安慰剂效应/Logistic回归/影响因素Key words
overactive bladder/ placebo response/ logistic regression/ influence factor引用本文复制引用
刘洪奕,邹琛,力弘,何兵..膀胱过度活动症治疗中安慰剂效应的影响因素分析[J].中国临床药学杂志,2013,22(4):226-229,4.
