中国脑血管病杂志2013，Vol.10Issue(7)：369-372,4.DOI:10.3969/j.issn.1672-5921.2013.07.008
手术与栓塞治疗颅内后循环动脉瘤的效果及对脑损伤相关因子的影响
Comparison of the effects and brain damage associated factors after surgical or embolization treatment of intracranial posterior circulation aneurysms
刘桂林 1李良 2莫大鹏2
作者信息
- 1. 北京市仁和医院神经外科 102600
- 2. 100034 北京大学第一医院神经外科
- 折叠
摘要
Abstract
Objective To investigate the effects of surgical and embolization treatment of intracranial posterior circulation aneurysms and their impact on brain damage associated factors during the treatment.Methods A total of 27 patients with intracranial posterior circulation aneurysms were diagnosed and treated in the Department of Neurosurgery,Peking University First Hospital from October 2011 to March 2012 were enrolled retrospectively.They were divided into either an surgical group (group A; n =12) or a embolization group (group B; n =15) according to their treatment modalities.The Glasgow Outcome Scale (GOS) scores after treatment,incidence of complications,recurrence rate,as well as the levels of serum S100B protein,MMP-9 and SOD before and after treatment were compared.Results ①The operation and hospitalization time and of group B were 89.6 ± 14.0 min and 14.1 ± 3.6 d respectively,and they were all shorter than 129.3 ± 21.4 min and 18.2 ± 4.0 d of group A.The differences were statistically significant between the two groups (P ＜ 0.05).②The good recovery rate of the GOS score of group B after treatment was 93.3％,and it was higher than 50.0％ of group A.The serum S100B protein and MMP at day 3 and 7 were lower than those of group A,while the SOD was higher than that of group A.The differences were statistically significant between the two groups (all P ＜0.05).Conclusion The clinical result of embolization of posterior circulation intracranial aneurysms is better,and the degree of brain tissue invasion is also minor.It is conducive to the rehabilitation of patients.关键词
颅内动脉瘤/显微外科手术/栓塞,治疗性/基质金属蛋白酶9/超氧化物歧化酶/S100B蛋白/后循环动脉瘤Key words
Intracranial aneurysms/Microsurgery/Embolization, therapeutic/Matrix metalloproteinase 9/Superoxide dismutase/S100B protein/Posterior circulation aneurysms引用本文复制引用
刘桂林,李良,莫大鹏..手术与栓塞治疗颅内后循环动脉瘤的效果及对脑损伤相关因子的影响[J].中国脑血管病杂志,2013,10(7):369-372,4.
