中国输血杂志2013，Vol.26Issue(6)：506-510,5.
在中华骨髓库找到HLA匹配无关供者的概率
Probability of finding HLA-matched unrelated marrow donor from Chinese Marrow Donor Program
赵桐茂 1洪俊岭 2刘静湖 2高东英 2刘琪 2杜丹 2韩颖 2鲁静 2徐刚3
作者信息
- 1. 中华骨髓库专家委员会,北京100007
- 2. 中国造血干细胞捐献者资料库管理中心
- 3. 紫光软件系统有限公司
- 折叠
摘要
Abstract
Objective To estimate the probability of finding HLA matched unrelated marrow donor in registry of Chinese Marrow Donor Program (CMDP).Discuss the optimal size of bone marrow donor registry in China.Methods The probability of finding at least one HLA matched unrelated donor was calculated based on the HLA phenotype frequency.Results The probability of finding HLA-A,-B,-DRB1 allele 6/6 matched,HLA-A,-B,-C,-DRB1 allele 8/8 matched and HLA-A,-B,-C,-DRB1,-DQB1 allele10/10 matched unrelated marrow donor in a pool of 248 978 donors from CMDP were 0.358 1,0.274 9,and 0.234 7,respectively.Based on the geographical region the Chinese can be classified into Northern Chinese (NCH) and Southern Chinese (SCH).The probability of finding 6/6,8/8,and 10/10 matched donor in NCH and SCH were 0.240 5 vs 0.338 3,0.180 7 vs 0.262 8,and 0.155 0 vs 0.222 5,respectively.The NCH showed a higher genetic variation than the SCH.Conclusion The donors in registry of CMDP could be derived into two genetically distinct North.ern and Southern groups.Selective recruitment of donors from certain geographical region may increase the probability of finding HLA-matehed donor.关键词
中华骨髓库/造血干细胞供者/HLA匹配概率/南北群体差异/最佳库容量Key words
donor from CMDP/probability of finding HLA-matched unrelated donor/Northern and Southern Chinese/optimal size of registry分类
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赵桐茂,洪俊岭,刘静湖,高东英,刘琪,杜丹,韩颖,鲁静,徐刚..在中华骨髓库找到HLA匹配无关供者的概率[J].中国输血杂志,2013,26(6):506-510,5.
