中国输血杂志2013，Vol.26Issue(6)：514-517,4.
拉萨藏族献血人群HPA-1～6、15基因多态性
The polymorphism of HPA-1 ～ 6,15 in Tibetan blood donors from Lhasa
摘要
Abstract
Objective To investigate the allele distribution of HPA-1 ～ 6,15 in Titetan blood donors from Lhasa.Methods The genotyping of HPA-1 ～ 6,15 were performed by the PCR with sequence-specific primers (PCR-SSP).A total of 405 healthy volunteer unrelated Tibetan blood donors were included.Results The allele frequencies of HPAs for 405Tibetan individuals were HPA-1a:0.9383,HPA-1b:0.061 7;HPA-2a:0.971 6,HPA-2b:0.028 4;HPA-3a:0.617 3,HPA-3b:0.382 7 ;HPA-4a:0.992 6,HPA-4b:0.007 4 ;HPA-5a:0.949 4,HPA-5b:0.050 6;HPA-6a:0.991 4,HPA-6b:0.008 6;HPA-15a:0.603.7,HPA-15b:0.396 3,respectively.The comparison with data of other ethnic groups showed that the allele frequencies of HPA-1,HPA-2,HPA-3,HPA-4,HPA-5 and HPA-15 were all significantly different between Tibetan and South Chinese Han (n =1 554).While compared with Xinjiang Khalkhas (n =105),such a significant difference was only found in HPA-2 system.The HPA-1b allele frequency in the Tibetan was significantly lower than that found in Caucasian from Germany (n =119),but significantly higher than the other compared Mongolian race except for Xinjiang Khalkhas.Conclusion Our study demonstrates that the distribution of HPA-1 ～6,15 in Tibetan exhibit unique characteristics.关键词
人类血小板抗原/多态性/藏族/PCR-SSPKey words
human platelet antigen/polymorphism/Tibetan/PCR-SSP分类
医药卫生引用本文复制引用
李梦丹,王珏,宋宁,辛友盼,李晓娟,扎西顿珠,刘忠,陈强..拉萨藏族献血人群HPA-1～6、15基因多态性[J].中国输血杂志,2013,26(6):514-517,4.基金项目
卫生部卫生公益性行业科研专项(200902008) （200902008）
