中国体外循环杂志2013，Vol.11Issue(2)：103-106,128,5.
心室辅助装置部分辅助对羊心脏血流动力学的影响
Partial support of the ovine heart with left ventricular assist device: implication for hemodynamic
摘要
Abstract
Objective In Vivo evaluation the hemodynamic changes of the left ventricular assist device assisted normal ovine hearts.Methods In this study,the ventricular assist device was implanted into the left ventricular apex on beating hearts.The outflow graft of each device was anastomosed to the descending aorta.The left ventricular-stroke volume (LVSV),mean arterial blood pressure (MAP),left atrial pressure (LAP),left ventricular pressure (LVP) peak diastolic,LVP peak systolic and heart rate (HR)were performed on schedule.Data associated with pump function were collected continuously.Results Five of the 8 animals survived over 24 hours.No thrombus formation or mechanical wearing was observed inside the pump.The partial support of the ovine heart with left ventricular assist device disrupted the normal sheep hemodynamic status,which increased cardiac output,reduced heart rate and left ventricular end-diastolic pressure.But no significant change was observed in mean arterial pressure and left atrial pressure.Conclusion The partial support of the normal ovine heart with left ventricular assist device can decrease the left ventricular workload; experimental animals can maintain a relatively normal cardiac hemodynamics status.关键词
心室辅助装置/部分辅助/在体实验/血液动力学Key words
Ventricular assist device/ Partial support/ In vivo test/ Hemodynamic分类
医药卫生引用本文复制引用
李海洋,吴广辉,蔺嫦燕,侯晓彤,陈琛,刘修健,徐创业,王璟,杨朋..心室辅助装置部分辅助对羊心脏血流动力学的影响[J].中国体外循环杂志,2013,11(2):103-106,128,5.基金项目
国家高技术研究发展863计划(20012AA041605)首都卫生发展科研专项项目(2011-1005-02) （20012AA041605）
