中国药房2013，Vol.24Issue(29)：2721-2723,3.DOI:10.6039/j.issn.1001-0408.2013.29.13
6种透皮吸收促进剂对盐酸普萘洛尔乳膏透皮吸收性能的影响
Effects of 6 Penetration Enhancers on Percutaneous Absorption of Propranolol Hydrochloride Cream
杨柳 1王爱武 2苗杰 1霍然 1徐广琪2
作者信息
- 1. 山东大学附属省立医院药剂科,济南250021
- 2. 山东中医药大学,济南250355
- 折叠
摘要
Abstract
OBJECTIVE:To investigate the effects of 6 penetration enhancers on percutaneous absorption of Propranolol hydrochloride cream,such as azone,oleic acid,propanediol,azone+oleic acid,azone+propanediol,oleic acid+propanediol.METHODS:Propranolol hydrochloride creams added with 6 penetration enhancers were prepared with penetration enhancers concentration of 2 ％.In vitro percutaneous absorption test of rats was performed with intelligent permeability instrument,and the contents of propranolol hydrochloride in 6 kinds of cream receptors were determined by HPLC.The accumulative transit dose (Q) and percutaneous permeability (J) within 12 h were calculated and compared with those of Propranolol hydrochloride cream without enhancer.RESULTS:With Q value as index,the action of 6 penetration enhancers in descending order was as follows:oleic acid [(2 552.01 ± 264.59) μg/cm2] ＞azone[(2 389.39 ± 346.45) μg/cm2] ＞oleic acid+propanediol[(2 082.04 ± 214.30) μg/cm2] ＞propanedio1[(1 852.92 ± 256.00) μg/cm2] ＞azone+oleic acid[(1 602.55 ± 13.56) μg/cm2] ＞azone+propanediol[(1 432.35 ± 149.02) μg/cm2] ＞no enhancer[(1 030.68 ± 98.00) μg/cm2],the same to the result with J value as index.CONCLUSIONS:6 kinds of penetration enhancers can enhance the percutaneous absorption of Propranolol hydrochloride cream with local administration,and oleic acid is the best.关键词
盐酸普萘洛尔/透皮吸收促进剂/透皮吸收性能/高效液相色谱法/大鼠Key words
Propranolol hydrochloride/Penetration enhancers/Percutaneous absorption/HPLC/Rats分类
医药卫生引用本文复制引用
杨柳,王爱武,苗杰,霍然,徐广琪..6种透皮吸收促进剂对盐酸普萘洛尔乳膏透皮吸收性能的影响[J].中国药房,2013,24(29):2721-2723,3.
