中国医科大学学报2013，Vol.42Issue(6)：481-484,4.
STOX1在子痫前期胎盘中的表达及意义
STOX1 Expression and Its Significance in Human Placentas from Preeclamptic Pregnancies
摘要
Abstract
Objective To study the mRNA and protein expression of STOX1 in placentas from normal pregnancies and patients with preeclampsia,so as to analyze the significance of the STOX1 expression in human placentas from preeclamptic pregnancies.Methods Immunohistochemistry,Western blot and real-time PCR were used to examine the expression of STOX1 in 20 normal pregnancies and 20 patients with preeclampsia.Results Immunohistochemistry results showed the STOX1 protein expression in the placentas of preeclampsias (85％,17/20) was much higher than that in the normal placenta (P ＜ 0.01).The expression of STOX1 was higher in placentas of the preeclampsias than that in non-cancerous pancreatic tissue at both protein and mRNA levels as detected by Western blot and real-time PCR respectively (t =8.608,P ＜ 0.01;t =14.659,P ＜ 0.01).Conclusion The expression of STOX1 was significantly increased in human placentas from preeclamptic pregnancies,which may have a correlation with the occurrence and development of preeclampsia.关键词
STOX1/子痫前期/胎盘组织/妊娠/滋养细胞Key words
STOX1/ preeclampsia/ placenta/ pregnancy/ trophoblast分类
医药卫生引用本文复制引用
赵鸽,孟涛,陈海英..STOX1在子痫前期胎盘中的表达及意义[J].中国医科大学学报,2013,42(6):481-484,4.基金项目
国家自然科学基金(81870711) （81870711）
