中国医科大学学报2013，Vol.42Issue(6)：515-517,3.
地西他滨联合半量CAG方案治疗老年性及复发难治性急性髓细胞白血病的疗效分析
Clinical Efficacy Analysis of Decitabine Combined with Half Quantity of CAG Regiment on Elderly and Refractory or Relapsed Acute Myeloid Leukemia
摘要
Abstract
Objective To evaluate the clinical efficacy of decitabine combined with half quantity of CAG regiment on elderly and refractory or relapsed acute myeloid leukemia (AML).Methods We collected clinical data of ten diagnosed cases of acute myeloid leukemia who were admitted to the First Affiliated Hospital of China Medical Uuniversity between Feb.2012 and Oct.2012.Results Of three newly diagnosed elderly patients,two achieved complete remission (CR),the overall response rate was 66.7％.Of seven refractory or relapsed patients,three cases achieved complete remission (CR),two cases achieved partial remission (PR),and the overall response rate was 71.4％.Hematologic toxicity was 100％,the incidence rate of infection was 70％,and mild liver injury was 30％.No severe bleeding,nausea and vomiting was observed.Conclusion Decitabine combined with half quantity of CAG regiment can effectively treat elderly and/or refractory or relapsed acute myeloid leukemia,but hematologic toxicity and infections is severe,it is necessary to give appropriate monitoring and supportive treatment.关键词
急性髓细胞白血病/地西他滨/半量CAG方案/不良反应Key words
acute myeloid leukemia/ decitabine/half quantity of CAG regiment/ adverse reaction分类
医药卫生引用本文复制引用
高然,张蕊,于锦香,高峰,蔡大利,王柏勋,潘登,颜晓菁,李艳..地西他滨联合半量CAG方案治疗老年性及复发难治性急性髓细胞白血病的疗效分析[J].中国医科大学学报,2013,42(6):515-517,3.基金项目
辽宁省医学高峰建设工程(2010010) （2010010）
沈阳市科学技术计划(F12-277-1-21) （F12-277-1-21）
