中国医科大学学报2013，Vol.42Issue(6)：551-556,6.
兔颈内动脉不同浓度丙泊酚输注药效学研究
Pharmacodynamic Study of Intracarotid Artery Propofol Infusion in Rabbits
尹红 1陈卫民 1朱俊超 1洪涛1
作者信息
- 1. 中国医科大学附属盛京医院麻醉科,沈阳110004
- 折叠
摘要
Abstract
Objective To study the rabbit EEG inhibition patterns of propofol via intracarotid artery and it's pharmacodynamic characteristics.Methods A total of 25 white rabbits were enrolled in this Dixon sequential study,and each animal received three sets of experiments.The rabbit cerebral state index (CSI) and EEG burst suppression (BS) changes were selected as the monitoring indicators.According to the Dixon sequential method,using 10 mg·kg 1·h 1 as a unit,three different concentrations of propofol (0.33 ％;0.5％; 1％) continuous infused to carotid artery for 10 min.If CSI appeared below 50,and BS above 0,the propofol infusion rate will be reduced to lower level for the next one.If there was no emergence of this state,the infusion rate will be raised in the next one.The changes of Cerebral State Index(CSI),Burst Suppression (BS) and other vital were observed at different time point of study (T1-T5).Probit test was used to calculate EC50 and EC95.Logistic regression analysis was applied to get the propofol concentration-effective probability curve.Results There were minor vital signs changes during experiment among the three groups.CSI values decreased after starting infusion of propofol.Regression analysis of Probit test revealed that EC50 and EC95 for group 0.5％ was the minimum (29.263 mg·kg-1·h-1)in three groups.Conclusion Continuous infusion of different concentrations of propofol via intracarotid artery of rabbits can reach EEG burst suppression depth of anesthesia.Higher concentration of continuous propofol infusion for 10 minutes to reach a certain depth of anesthesia required wide range of delivery speed.The stability of required infusion rate would be improved by reducing drug concentrations.关键词
颈内动脉/给药系统/丙泊酚/药效学Key words
drug delivery system/ diprivan/ intracarotid infusion/ pharmacodynamics分类
医药卫生引用本文复制引用
尹红,陈卫民,朱俊超,洪涛..兔颈内动脉不同浓度丙泊酚输注药效学研究[J].中国医科大学学报,2013,42(6):551-556,6.
