中国药业2013，Vol.22Issue(10)：35-36,2.
药物中间体2-(2'-羟基-4'-氨基苯基)苯并噻唑的合成工艺改进
Improved Synthesis Technology of Drug Intermediate 2-(2-Hydroxy-4'-Aminophenyl)Benzothiazole
陈卓 1陈研明2
作者信息
- 1. 西安医学院药学院,陕西西安 710021
- 2. 西安交通大学医学院,陕西西安 710049
- 折叠
摘要
Abstract
Objective To improve the synthesis technology of 2-(2-Hydroxy-4'-aminophenyl) benzothiazole.Methods With oamino-thiophenol and aminosalicylate as the raw materials,the synthesis method was improved through etherification and Vilsmeier reaction.Results The reaction yield rate was increased from 50％ to 81.7％,the reaction temperature was decreased from 150 ℃ to mild 50 ℃,and the reaction time was shortened from 3 h to 45 min.Conclusion The improved technology not only reduces the cost,but also increases the environmental friendliness of the reaction.关键词
2-(2'-羟基-4'-氨基苯基)苯并噻唑/三甲基氯硅烷/合成工艺Key words
2-(2-hydroxy-4'-aminophenyl) benzothiazole / trimethylchlorosilane (TMSC1) / synthesis technology分类
医药卫生引用本文复制引用
陈卓,陈研明..药物中间体2-(2'-羟基-4'-氨基苯基)苯并噻唑的合成工艺改进[J].中国药业,2013,22(10):35-36,2.
