摘要
Abstract
Objective To evaluate the effect and safety of Bailing Capsule combined with the conventional treatment for treating early disbetic nephropathy.Methods The Cochrane Library (Issue 1,2012),EMbase,PubMed,CBM,CNKI and VIP(from their establishment to October 2012) were retrieved by computer for collecting the randomized controlled trials(RCTs) of Bailing Capsule combined with the conventional treatment for treating early disbetic nephropathy.The data were performed the meta analysis by RevMan 5.14 software.Results Twenty-nine RCTs involving 1 601 patients were ultimately identified.The Results of meta-analyses showed that,compared with the control group,the urinary albumin excretion rate(UAER) of the Bailing Capsule group was lower than that of the control group [MD =-27.41,95％ CI(-32.82,-21.99),P ＜ 0.000 01];the 24h UMA of the Bailing Capsule group was lower than that of the control group,[MD =-48.95,95％ CI(-67.66,-30.25),P ＜ 0.000 01] ;the serum SCr of the Bailing Capsule group was lower than that of the control group,[MD =-6.34,95％ CI(-10.94,-1.75),P ＜ 0.000 01] ; the BUN of the Bailing Capsule group was lower than that of the control group,[MD =-0.49,95％ CI(-0.97,-0.01),P =0.04];the effective rate of the Bailing Capsule group was higher than that of the control group,[OR=4.98,95％ CI(3.12,7.95),P ＜ 0.000 01].The fasting plasma glucose(FPG) of the Bailing Capsule group was lower than that of the control group without statistically significant difference between them [MD =-0.02,95％ CI(-0.28,0.23),P =0.86].No serious adverse reactions were found in the two groups.Conclusion Based on the present clinical evidences,Bailing Capsule combined with the conventional treatment for treating early disbetic nephropathy is effective with good safety.Howerver,due to the quality disunity of the included studies,this Conclusion need more large sample size,high-quality RCTs to confirm.关键词
百令胶囊/早期糖尿病肾病/随机对照试验/系统评价Key words
Bailing Capsule/ early diabetic nephropathy/ randomized controlled trial / systematic review分类
医药卫生
