中国药业2013，Vol.22Issue(14)：42-43,2.
家兔灌服磷化铝中毒的解毒方法研究
Study on Detoxification of Aluminium Phosphide Poisoning in Rabbits
摘要
Abstract
Objective To select the detoxification-type gastric lavage agents with the effect of preventing the generation of hydrogen phosphide,and to find the best scheme for the early treatment of oral aluminium phosphide(AlP) poisoning.Methods Forty-eight rabbits were divided into 6 groups,intragastrically lavaged by the minimum lethal dose (LDmin) of AlP,then immediately lavaged by 1％ CuSO4,0.02％ KMnO4,edible oil,liquid paraffin or sustained gastrointestinal decompression respectively.The rabbit arterial blood was collected for the blood gas analysis before AIP lavage,at 0.5 h after AIP lavage and death.The rabbit death time was recorded.Results The average survival time was (105.25 +23.38) mmin in the edible oil lavge group and (4 200±63.22) min in the sustained gastrointestinal decompression group,which were significantly longer than those in other groups with statistical difference (P ＜ 0.05 or P ＜0.01).Conclusion Gastric lavage with edible oil and sustained gastric decompression are the key to increase the survival rate for rescuing AlP poisoning.关键词
磷化铝/中毒/洗胃剂/胃肠减压Key words
AlP/ poisoning/ gastric lavage agents/ gastrointestinal decompression分类
医药卫生引用本文复制引用
王锦文,杨亚非,龙晓东,李奕璇,王梓,刘子梦,刘涛..家兔灌服磷化铝中毒的解毒方法研究[J].中国药业,2013,22(14):42-43,2.基金项目
云南省科技厅基金项目,项目编号:2009ZC172M. （）
