摘要
Abstract
Objective To evaluate the clinical effect and safety of the basic treatment plus the adjuvant therapy of cattle encephalon glycoside and ignotin in treating neonatal hypoxie-ischemic encephalopathy (HIE).Methods MEDLINE,EMBase,Cochrane Library,CBM,CNKI,VIP and Wanfang database were systematically retrieved for collecting the randomized controlled trials (RCT) of the basic treatment plus the adjuvant therapy of encephalon glycoside and ignotin and simple basic treatment in treating neonatal HIE.The included studies were performed the quality evaluation and the meta-analysis on the homogeneity studies.Results A total of 11 RCTs were included,scoring 3 by the Jadad scoring method.The meta-analysis results indicated that the significantly effective rates had statistical difference between the two groups[RR=1.81,95％ CI(1.53,2.14)];the neonatal behavioral neurological assessment (NBNA) scores had statistical difference between the two groups [MD=4.30,95％ Cl(2.24,6.35)];the differences in the the recovery time of the consciousness disturbance,seizures stop,anterior fontanel tension,primitivie reflex and muscular tension between the study group and the control group had statistical significance,[MD(95％ CI) was-1.6(-2.15,-1.07),-1.21 (-1.84,-0.59),-1.53 (-2.07,-0.99),-2.27 (-3.10,-1.43) and-1.66 (-2.42,-0.90) respectively].Conclusion Based on the present clinical studies,adding cattle encephalon glycoside and ignotin on the basic treatment for treating neonatal HIE can increase the effect with good safety.关键词
脑苷肌肽/新生儿缺氧缺血性脑病/Meta分析Key words
cattle encephalon glycoside and ignotin/neonatal hypoxie-ischemic encephalopathy/Meta-analysis分类
医药卫生
