高等学校化学学报2013，Vol.34Issue(8)：1858-1862,5.DOI:10.7503/cjcu20130279
白屈菜红碱的全合成
Total Synthesis of Chelerythrine
摘要
Abstract
Chelerythrine is an isoquinoline alkaloid isolated from Herba Chelidonii that possess complex structure and remarkable activities.In this work,its total synthetic approach was investigated.Key meditate methyl 6-iodo-2,3-dimethoxybenzoate (7) was obtained in six steps with (6-bromo-2,3-dimethoxyphenyl) methanol (1) as starting material.The core structure was efficiently constructed by palladium-catalyzed tandem reaction in one step.At the same time,a proposed mechanism of palladium-catalyzed tandem reaction was suggested and the chelerythrine was synthesized in 10 steps with a total yield of 60.9％.All compounds were confirmed by IR,1H NMR,13C NMR and high resolution mass spectrometer(HRMS).关键词
苯并[c]菲啶/白屈菜红碱/全合成Key words
Benzo[c]phenanthridine/ Chelerythrine/ Total synthesis分类
化学化工引用本文复制引用
黄康伦,谢龙观,吕培,郭翠,徐效华..白屈菜红碱的全合成[J].高等学校化学学报,2013,34(8):1858-1862,5.基金项目
国家科技支撑计划项目(批准号:2011BAE06B05)资助. （批准号:2011BAE06B05）
