内科理论与实践2013，Vol.8Issue(4)：241-245,5.DOI:10.3969/j.issn.1673-6087.2013.04.003
吡格列酮对非酒精性脂肪性肝病患者的氧化应激参数和炎症因子的影响
Effects of pioglitazone on oxidative stress-related parameters and inflammatory cytokines in patients with nonalcoholic fatty liver disease
摘要
Abstract
Objective To investigate the effect of pioglitazone on oxidative stress-related parameters and inflammatory cytokines in patients with nonalcoholic fatty liver disease (NAFLD).Methods In this randomized,singleblind,controlled study,106 patients with NAFLD without diabetes were randomized into two groups.Fifty-two patients in the pioglitazone group received pioglitazone 30 mg/d with a course of 24 weeks,while the other 54 patients were served as controls.The levels of serum alanine aminotransferase (ALT),gamma-glutamyl transferase (GGT),free fatty acids (FFA),malondialdehyde (MDA),4-hydroxy-2-nonenal (4-HNE),interleukin (IL)-1β,IL-6,tumor necrosis factor-α (TNF-α),CT value ratio of liver and spleen,and homeostatic model assessment for insulin resistance (HOMA-IR) were measured before and after treatment.Results There were no significantly differences in baseline characteristics between two groups (P＞ 0.05).After 24 weeks treatment,CT value ratio of liver and spleen increased (P＜0.05),and the levels of serum ALT,GGT,FFA,MDA,4-HNE,IL-1β,IL-6,TNF-α and HOMA-IR decreased in pioglitazone group (all P＜0.05),and no obvious changes was observed in control group.No serious adverse reaction was observed in pioglitazone group.Conclusions Pioglitazone may decrease hepatic fat content and levels of oxidative stress-related parameters and inflammatory cytokines in patients with NAFLD.关键词
吡格列酮/非酒精性脂肪性肝病/氧化应激/炎症因子/肝/脾CT比值Key words
Pioglitazone/ Nonalcoholic fatty liver disease/ Oxidative stress-related parameter/ Inflammatory cytokine/ CT value ratio of liver and spleen分类
医药卫生引用本文复制引用
方文军,陆帅,王娟,胡静芳,苏青..吡格列酮对非酒精性脂肪性肝病患者的氧化应激参数和炎症因子的影响[J].内科理论与实践,2013,8(4):241-245,5.基金项目
上海市卫生局课题(项目编号:2009238) （项目编号:2009238）
