实用妇产科杂志2013，Vol.29Issue(8)：617-619,3.
HC2 HPV检测在宫颈病变筛查中的临床应用
Clinical Application of HC2 HPV Testing in the Screening of Cervical Lesions
黄江渝 1杨淑哲 1贺苇军 1唐建1
作者信息
- 1. 成都市妇女儿童中心医院,四川成都610091
- 折叠
摘要
Abstract
Objective:To analyze situation of human papillomavirus (HPV) infection in women of childbearing age and to explore a new strategy for screening cervical lesions in clinic.Methods:2070 physical examination individuals (physical examination group) and 1405 gynecologic outpatients (outpatient group) were selected randomly to test HPV using hybrid capture Ⅱ assay (HC2),297 cases were selected randomly from 1405 outpatients to test HPV both by HC2 and thinprep cytologic test(TCT).Results:①The positive rates of HPV infection in physical examination group(all cases) and outpatient group(all cases) are 12.17％ and 21.28％,the difference between the two groups was significant(P＜0.01).The positive rates of HPV infection in physical examination group were significantly higher than those in outpatient group (P ＜ 0.01) when the patients' ages were 30 to 39 years old,40 to 49 years old,and older than 50 years old.In physical examination group,the highest infection rate was in the individuals who were aged 20 ～ 29 years old (20.00％) ;In outpatient group the highest infection rate was in the individuals who were older than 50 years old (36.50％) ②.The individuals in the outpatient group who were tested by both TCT and HC2 were regarded as positive when their result of TCT was LSIL,or more severe.The positive predictive value and negative predictive value was 15.87％ (30/189),100％ (108/108) respectively.Conclusions:HPV testing in gynaeco-logical outpatients is good for cervical lesion screening.Secondary cervical cytological examination after the positive result of HC2 HPV test may be a new strategy for screening cervical lesions.关键词
人乳头瘤病毒/宫颈病变/杂交捕获2代技术检测/液基细胞学检测Key words
Human papillomavirus/ Cervical lesions/ Hybrid capture Ⅱ assay methods/ Thinprep cytologic test分类
医药卫生引用本文复制引用
黄江渝,杨淑哲,贺苇军,唐建..HC2 HPV检测在宫颈病变筛查中的临床应用[J].实用妇产科杂志,2013,29(8):617-619,3.
