中国康复2013，Vol.28Issue(4)：286-288,3.DOI:10.3870/zgkf.2013.04.019
康复预处理对实验性自身免疫性脑脊髓炎小鼠IL-23/IL-17轴的影响
Effects of rehabilitation pretreatment on IL-23/IL-17 axis of mice with experimental autoimmune encephalomyelitis
摘要
Abstract
Objective:To explore the effects of rehabilitation pretreatment (RT) on interleukin-23 (IL-23)/IL-17axis of mice with experimental autoimmune encephalomyelitis (EAE).Methods:After C57BL/6 mice were subjected to rehabilitation pretreatment (treadmill training),EAE model was induced in mice,and EAE group and RT-EAE group were established.Normal mice were selected as control group.The mean neurobehavioral scores were measure,and the serum levels of IL-23 and IL-17 were detected by using ELISA.Results:The mean neurobehavioral scores in RT-EAE group were significantly lower than in EAE group (1.44±0.56 vs.2.75±1.13,P＜0.05).Theexpression of IL-23 and IL-17 in EAE group was significantly higher than in control group and RT-EAE group (P＜0.05).Conclusion:RT can delay the occurrence of EAE probably by inhibiting the IL-23/IL-17 axis.关键词
实验性自身免疫性脑脊髓炎/康复预处理/IL-23/IL-17轴Key words
experimental autoimmune encephalomyelitis/ rehabilitation pretreatment / IL-23/IL-17 axis分类
医药卫生引用本文复制引用
许秋生,唐强,朱路文..康复预处理对实验性自身免疫性脑脊髓炎小鼠IL-23/IL-17轴的影响[J].中国康复,2013,28(4):286-288,3.基金项目
黑龙江省2012年研究生创新科研资金项目(YJSCX2012-346HLJ) （YJSCX2012-346HLJ）
