肿瘤防治研究2013，Vol.40Issue(7)：698-701,4.DOI:10.3971/j.issn.1000-8578.2013.07.015
长春瑞滨联合希罗达对蒽环类/紫杉类治疗后复发转移性乳腺癌的疗效观察
Effects of Vinorelbine Combined with Xeloda in Anthracycline-and Taxane-pretreated Patients with Relapsed Metastatic Breast Cancer
王楠 1代醒 1王留兴1
作者信息
- 1. 450052 郑州,郑州大学第一附属医院肿瘤科
- 折叠
摘要
Abstract
Objective To evaluate the short-term efficacy and adverse reactions of vinorelbine combined with xeloda to patients with recurrent and metastatic breast cancer after taxane and anthracycline treatment.Methods Forty patients with recurrent metastatic breast cancer after taxane and anthracycline treatment were recruited.Vinorelbine 25 mg/m2 on day 1 and day 8,eapecitabine 1 000 mg/m2,twice daily on day 1 to 14.Three weeks was one cycle.At least two cycles were given to each patient.Results Of the 40 patients,3 achieved CR,17 achieved PR,16 achieved SD,4 achieved PD,with a total response rate of 47.5％,with a clinical benefit response 70％.The median time to disease progression was 8.5 months.The common adverse reactions were myelosuppression,gastrointestinal reactions,hand-foot syndrome and neurotoxicity.Conclusion vinorelbine combined with capecitabine is an effective rigmens in the treatment of patients with relapsed and metastatic breast cancer,especially for those who have failed in chemotherapy with taxane and anthracycline.The therapy is well tolerated but has mild adverse reactions.关键词
复发转移性乳腺癌/长春瑞滨/希罗达/化疗Key words
Metastatic breast cancer/ Vinorelbine/ Xeloda/ Chemotherapy分类
医药卫生引用本文复制引用
王楠,代醒,王留兴..长春瑞滨联合希罗达对蒽环类/紫杉类治疗后复发转移性乳腺癌的疗效观察[J].肿瘤防治研究,2013,40(7):698-701,4.
