安徽农业大学学报2013，Vol.40Issue(3)：418-421,4.
甲状腺素联合多奈哌齐对成年期甲减大鼠海马SNAP-25的影响
Effects of thyroxine and donepezil on hippocampal SNAP-25 expression in hypothyroid adult rats
摘要
Abstract
We evaluated the effects of thyroxine and donepezil on hippocampal SNAP-25 expression in adult hypothyroidism rats,and clarified the possible mechanism under the hypothyroidism-induced cognitive dysfunction.Our data showed that the serum T3 and T4 levels were significantly lower in the hypothyroid group rats than those in the control group rats.After thyroxine or combined with donepezil treatment,serum T3 and T4 were returned to the normal.Compared to the control group,the immunoreactivity of SNAP-25 in CA1,CA3 and DG regions of hippocampus was significantly increased.A two-week treatment with T4 alone failed to normalize the expression of SNAP-25,however,there was no significant difference in SNAP-25 protein levels after coadministration of thyroxine and dozepezil.These results suggested that adult-onset hypothyroidism induced increment of SNAP-25 in the hippocampus,which could be restored by thyroxine combined with dozepezil treatment.关键词
甲状腺功能减退症/甲状腺素/多奈哌齐/SNAP-25/海马Key words
hypothyroidism/ thyroid hormone/ dozepezil/ SNAP-25/ hippocampus分类
医药卫生引用本文复制引用
郑燕,朱德发..甲状腺素联合多奈哌齐对成年期甲减大鼠海马SNAP-25的影响[J].安徽农业大学学报,2013,40(3):418-421,4.基金项目
国家自然科学基金项目(81272152)资助. （81272152）
