广东医学2013，Vol.34Issue(13)：2022-2026,5.
心力衰竭患者B型利钠肽、B型氨基端利钠肽原和可溶性ST2水平变化及意义
The clinical significance of B-type natriuretic peptide, N-terminal pronatriuretic peptide and soluble ST2 monitoring in patients with heart failure
摘要
Abstract
Objective To evaluate the clinical significance of B-type natriuretic peptide (BNP),N-terminal pronatriuretic peptide (NT-proBNP) and serum soluble ST2 (sST2) monitoring.Methods A total of 179 patients with and without symptoms of heart failure (HF) were included in this retrospective study.According to the classification criteria of New York Heart Association (NYHA),eighty-four HF patients were regarded with the observation group (HF group),while the other 95 contemporaneous in-patients without HF were assigned as control group.The serum concentrations of BNP and sST2 were measured by enzyme-linked immunoabsorbent assay,while NT-proBNP was assessed by the immunochromatographic assay.Associations between BNP,NT-proBNP,sST2 and left ventricular ejection fraction (LVEF) were analyzed; additionally,the serum concentration changes of BNP,NT-proBNP,sST2 according to NYHA cardiac classes were viewed and compared.Results There were significant differences in BNP,NT-proBNP and sST2 concentrations between HF group and control group (P ＜ 0.01).They were significantly increased in patients with HF;and positively correlated with NYHA class but negatively correlated with LVEF.The blood concentrations of the markers were higher along with NYHA classification of cardiac function (P ＜ 0.05).According to receiver operating characteristic curve analysis,ther area under the curve for BNP,NT-proBNP and sST2 were 0.868,0.957 and 0.758,respectively,for the diagnosis of HF.Conclusion BNP,NT-proBNP and sST2 are novel biomarker for cardiac stress in patients with HF,and can be used diagnosing HF and evaluating cardiac function.In HF diagnosis,NT-proBNP is superior to BNP and sST2.关键词
心力衰竭/B型利钠肽/B型氨基利钠肽原/可溶性ST2Key words
heart failure / B-type natriuretic peptide / N-terminal pronatriuretic peptide / soluble ST2引用本文复制引用
杨阳,罗义..心力衰竭患者B型利钠肽、B型氨基端利钠肽原和可溶性ST2水平变化及意义[J].广东医学,2013,34(13):2022-2026,5.基金项目
广州市医药卫生科技一般引导项目立项资助项目(编号:2009-YB-004) （编号:2009-YB-004）
