国际妇产科学杂志2013，Vol.40Issue(4)：375-378,封3,5.
E-钙黏素和β-连环素在子宫内膜癌组织中表达状况的研究
Expression of E-cadherin and Beta-catenin in Endometrial Carcinoma
冯兰青 1王明波 1王晓萍 1刘穗 1陈昌伟2
作者信息
- 1. 523110广东省东莞市,东莞东华医院妇科
- 2. 523110广东省东莞市,东莞东华医院病理科
- 折叠
摘要
Abstract
Objective:To detect the relationship between expression of E-cadherin and beta-catenin with endometrial carcinoma.Methods:A total of 65 specimens of endometrial carcinoma,38 normal endometrial tissues and 36 atypical hyperplasia endometrium tissues were evaluated by immunohistochemical technique with monocolonal antibodies against E-cadherin and beta-catenin.Results:The aberrant expression rates of E-cadherin and beta-catenin increased obviously from normal endometrial tissues,atypical hyperplasia endometrium tissues to endometrial carcinoma tissues (P＜0.05).Expression of E-cadherin was positively correlated with tumor grade,mymetrial invasion,surgical stage and lymphnode matastasis (P＜0.05).Expression of beta-catenin was also significantly correlated with tumor grade,surgical stage and lymphnode matastasis (P＜0.05).Conclusions:The aberrant expression of E-cadherin and beta-catenin was positively related to oncogenesis,invasion,metastasis and prognosis of endomentrial carcinoma.It should be considered to a certain extent as an index of malignant degree and prognosis of endomentrial carcinoma.关键词
钙黏着糖蛋白类/β连环素/子宫内膜肿瘤/免疫组织化学Key words
Cadherins / Beta catenin / Endometrial neoplasms/ Immunohistochemistry引用本文复制引用
冯兰青,王明波,王晓萍,刘穗,陈昌伟..E-钙黏素和β-连环素在子宫内膜癌组织中表达状况的研究[J].国际妇产科学杂志,2013,40(4):375-378,封3,5.
