国际生殖健康/计划生育杂志2013，Vol.32Issue(3)：191-193,197,4.
人卵丘细胞与卵子发育潜能关系的研究进展
Research Progress of the Relationship between Human Cumulus Cells and Oocyte Developmental Potential
叶田1
作者信息
- 1. 450052 郑州大学第一附属医院生殖医学中心
- 折叠
摘要
Abstract
There is a close relationship between human cumulus granulosa cells and oocytes,because the former could influence the development and maturation of oocytes and therefore the embryos quality.In assisted reproductive technology,study on cumulus granulosa cells may offer us more objective,accurate and noninvasive criteria for embryo selection so that the pregnancy rates can be increased and the elective single embryo transfer protocol can be promoted.On the other hand,the high order multiple pregnancy rates and the poor outcomes can be also decreased considerably.Nowadays,it is a hot area to explore the relationship between cumulus cells and oocyte developmental potential at the genetic and transcriptional levels.It was reported that the up-regulation of oogenesis-related genes in cumulus cells can predict good quality embryos.Checkpoints and DNA repair-related genes are associated with oocyte quality.Cell apoptosis,glucogenesis,antioxidative stressrelated genes and transcription factor NFIB are the biological parameters to predict the oocyte developmental potential and pregnancy outcome.关键词
卵丘细胞/卵子发生/生殖技术,辅助/胚胎移植/妊娠结局Key words
Cumulus cells/Oogenesis/Reproductive techniques, assisted/Embryo transfer/Pregnancy outcome引用本文复制引用
叶田..人卵丘细胞与卵子发育潜能关系的研究进展[J].国际生殖健康/计划生育杂志,2013,32(3):191-193,197,4.
