哈尔滨商业大学学报（自然科学版）2013，Vol.29Issue(3)：265-270,6.
马钱子总生物碱树脂复合物的制备及结合机制
Preparation and determination of combined mechanisms for composites of Strychnos total alkaloids-resin
摘要
Abstract
This paper designed to prepare strong acidic cation-exchange resin composites of total alkaloids from the Strychnos and determined the combined mechanisms between total alkaloids and resin.Used electrostatic exchange method,took strong acidic cation-exchange resin as drug carrier,the total alkaloids from Strychnos as model drug,Strychnin as index components.Based on the type and particle size of resin,ionic strength of dissolved total alkaloids solution,dosage of total alkaloids and resin,and reaction temperature,investigated the ion exchange reaction rate and equilibrium problem of index components under different conditions.The optimum process to prepare the composites of Strychnos total alkaloids-resin by electrostatic exchange method was dissolving total alkaloids by 0.1 mol/L HCl to prepare total alkaloids solution of Strychnos whose concentration was 2 mg/mL,reacting with H +ion exchange resin which its particle size was 0.080 ～ 0.096 mm at 50 ℃.The differential scanning detection showed that Strychnos alkaloids combined with ion exchange resin was through ionic bonds instead of simple physical adsorption.关键词
马钱子总生物碱/士的宁/马钱子碱/离子交换树脂/静态法制备Key words
total alkaloids of Strychnos / strychnin / brucine / ion exchange resin / electrostatic method分类
医药卫生引用本文复制引用
李伟男,于鑫,王莹莹,曹欢,张智慧,李洋,王艳宏..马钱子总生物碱树脂复合物的制备及结合机制[J].哈尔滨商业大学学报（自然科学版）,2013,29(3):265-270,6.基金项目
黑龙江省研究生创新科研基金(YJSCX2011-457HLJ),黑龙江中医药大学科研基金项目(201005). （YJSCX2011-457HLJ）
