实用临床医药杂志2013，Vol.17Issue(11)：31-33,3.DOI:10.7619/jcmp.201311010
甲泼尼松龙与布地奈德治疗加重期慢性阻塞性肺疾病的疗效比较
Comparing therapeutic effects of methylprednisolone and budesonide on acute exacerbation of chronic obstructive pulmonary disease
摘要
Abstract
Objective To explore the therapeutic effects of methylprednisolone and budesonide for acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods Sixty patients with AECOPD were randomly divided into budesonide group,methylprednisolone group and control group,20 cases in each group.All patients were given routine treatment during treatment,including administration of bronchodilators and antibiotics,meanwhile,oxygen therapy was also applied.Patients in budesonide group were given aerosol inhalation,those in methylprednisolone group given intravenous drip of methylprednisolone,whereas those in control group not given any hormones.On the day of admitting into hospital and after treatment,all patients were detected lung function and arterial blood gases,and clinical symptom score was also conducted.The condition of adverse reactions was observed in 2 groups during treatment.Results After treatment,clinical symptom scores in each group all decreased remarkably,and those in budesonide and methylprednisolone groups were obviously lower than that in control group,and that in methylprednisolone group significantly lower than that in budesonide group.Compared with treatment before,the forced expiratory volume in 1 second (FEV1) in each group after treatment conspicuously increased.FEV1 in budesonide and methylprednisolone groups after treatment was significantly higher than that in control group,in which that in methylprednisolone group was markedly higher than that in budesonide group.PaO2 in budesonide and methylprednisolone groups after treatment obviously elevated,whereas PaCO2 notably reduced,both differences were significant by comparison to treatment after.Conclusion Aerosol inhalation of budesonide can distinctly ameliorate the lung function of patients with AECOPD,with the same therapeutic effect as methylprednisolone.关键词
慢性阻塞性肺疾病/急性加重期/布地奈德/甲泼尼松龙Key words
chronic obstructive pulmonary disease/ acute exacerbation/ budesonide/methylprednisolone分类
医药卫生引用本文复制引用
张颖,方维军,魏俊平..甲泼尼松龙与布地奈德治疗加重期慢性阻塞性肺疾病的疗效比较[J].实用临床医药杂志,2013,17(11):31-33,3.基金项目
中国高校医学期刊临床专项资金(11320131) （11320131）
