实用临床医药杂志2013，Vol.17Issue(11)：53-55,3.DOI:10.7619/jcmp.201311017
三氧化二砷联合沙利度胺对骨髓增生异常综合征的调节作用
Regulatory effects of arsenic trioxide combined with thalidomide on myelodysplastic syndrome
摘要
Abstract
Objective To explore the regulatory effects of arsenic trioxide combined with thalidomide on myelodysplastic syndrome (MDS).Methods Forty-six patients with MDS were divided into two groups randomly,23 cases in each group.The treatment group was treated with arsenic trioxide combined with thalidomide,while the control group with arsenic trioxide alone.Two months later,the total therapeutic effects of 2 groups were assessed,and hemoglobin (Hb),absolute of neutrocytes (ANC),blood platelet count (PLT),proportion of original cells in bone marrow and adverse reaction of 2 groups were compared.Results The total effectiveness rate in the treatment group was obviously higher than that in the control group.The improving condition of Hb,ANC,PLT and proportion of original cells in bone marrow in the treatment group were obviously superior to those in the control group.The incidence of adverse reactions of 2 groups showed no significant difference.Conclusion Compared with the usage of arsenic trioxide alone,its combined with thalidomide can significantly improve trilineage blood cells,decrease the proportion of original cells in bone marrow,and improve the short-term therapeutic effect,without more adverse reactions.关键词
生物反应调节剂/沙利度胺/三氧化二砷/骨髓增生异常综合征Key words
biological response modifier/ thalidomide/ arsenic trioxide/ myelodysplastic syndrome分类
医药卫生引用本文复制引用
王静霞,张秋荣..三氧化二砷联合沙利度胺对骨髓增生异常综合征的调节作用[J].实用临床医药杂志,2013,17(11):53-55,3.基金项目
中国高校医学期刊临床专项资金(11320102) （11320102）
