实用临床医药杂志2013，Vol.17Issue(14)：21-24,4.DOI:10.7619/jcmp.201314007
非小细胞肺癌前哨淋巴结扫描活检术的临床研究
Clinical study on sentinel lymph node dissection in non-small cell lung cancer
摘要
Abstract
Objective To explore the feasibility of sentinel lymph node (SLN) detection in the radical resection of non-small cell lung cancer (NSCLC).Methods Twenty-four patients with resectable NSCLC were selected.SLN was removed by operation,and systemic hilum of the lung and mediastinal lymphadenectomy were performed.All removed lymph nodes were given routine HE staining examination.Immunohistochemistry keratin staining method was combined to detect whether there was a micrometastasis.Results The SLN detection rate in 24 patients was 100％,with a total of 50 SLN,and 143 non-sentinel lymph nodes (NSLN) were found.HE staining demonstrated that cancer metastasis occurred to both 31 out of the 50 SLN and 27 out of the 143 NSLN.The probabilities of sentinel lymph node biopsy (SLNB) and positive lymph nodes removed by radical mediastinal lymph node dissection were 62％ and 30.1％,respectively.As a monoclonal antibody,CK-19 was detected by immunohistochemistry.It was found through CK-19 that the metastasis occurred in 2 out of 4 SLN patients with negative SLN stained with routine HE,which improved the sensitivity of lymph node status in SLNB predictive region from 95.45％ to 100％ and accuracy rate from 95.83％ to 100％,whereas it decreased the false negative rate from 4.55％ to 0％.The 1 1th site was the most common occurrence site of SLN,then the 12th site,mediastinal lymph nodes (5 and 6) and 10th site.Conclusion SLN can be used to predict whether the metastasis occurs in the hilum of the lung and mediastinal lymph nodes in NSCLC.关键词
前哨淋巴结/非小细胞肺癌/微转移Key words
sentinel lymph node/ non-small cell lung cancer/ micrometastasis分类
医药卫生引用本文复制引用
纪波,王启飞,张志辉,穆玉恕..非小细胞肺癌前哨淋巴结扫描活检术的临床研究[J].实用临床医药杂志,2013,17(14):21-24,4.基金项目
中国高校医学期刊临床专项资金(11321050) （11321050）
