摘要
Abstract
Objective To assay the serum omentin and vifastin level in newly diagnosed type 2 diabetes mellitus(T2DM)patients and investigate the relationship between serum omentin level and body fat parameters,glycolipid metabolism and visfatin levels.Methods The fasting serum levels of omentin and vifatin were detected by ELISA in 45 T2DM patients and 28 healthy controls.Meanwhile,detas were also abstained including blood glucose,HbA1c,lipids,insulin levels,body mass index(BMI),waist hip ratio(WHR)and insulin resistance index(HOMA-IR).The relationship of serum omentin level and those indictors was analyzed.Results Compared with the control group,the serum omentin level was significantly lower and visfatin level was significantly higherinT2 DMgroup [(6 8.6 ± 11.2 7) μg/Lvs (2 9.8 ± 5.19) μg/L,(9.3 7 ± 0.8 5) μg/Lvs (18.67 ±7.98) μg/L,P＜0.05].Partial correlation analysis showed that negatively correlated to WHR,HOMA-IR,triglycerides (TG),2 hourOGTTglucose (2 hPG) and visfatin (r =-0.31,-0.29,-0.46,-0.376,and-0.040 respectively,P ＜ 0.05).Conclusion The serum omentin level is correlated with glycolipid metabolism.Serum omentin may contributed to the pathogenesis of diabetes mellitus.关键词
糖尿病/网膜素/内脂素/糖脂代谢Key words
diabetes mellitus/ omentin/ visfatin/ glycolipid metabolism分类
医药卫生
