昆明医科大学学报2013，Vol.34Issue(7)：25-29,5.
外源性碱性成纤维细胞生长因子诱导下自体静脉桥接修复面神经缺损
The Vein Graft Technique of the Facial Nerve Regeneration Combined with the Induce of Basic Fibroblast Growth Factor
摘要
Abstract
Objective To investigate the effect of the vein graft technique combined with the basic fibroblast growth factor (bFGF) on peripheral nerve regeneration.Metheds:12 adult white rabbits were selected and divided into two groups.The facial nerve on the left side of rabbits was served and bridged with the autogenous standard of vein graft.0.3ml bFGF solution (0.75 μg/mL) was injected into the vein graft conduit in the experimental group,while the same amount of saline solution was used in the control group.Microscopic examination and detection of nerve conduct velocity were performed at 100 th day after the operation.Results At 100th day nerve regeneration in the vein graft combined with bFGF showed there were superior functional results of faster conduction velocities (P＜0.05) and distinct histological results compared with the control group.Conclusion The vein graft technique combined with bFGF can induce the facial nerve to regenerate.关键词
碱性成纤维细胞生长因子/静脉桥接/神经缺损/神经再生Key words
Basic fibroblast growth factor/ Vein graft/ Nerve defect/ Nerve regeneration分类
医药卫生引用本文复制引用
张敏,许彪,江勋,张立亚..外源性碱性成纤维细胞生长因子诱导下自体静脉桥接修复面神经缺损[J].昆明医科大学学报,2013,34(7):25-29,5.基金项目
国家自然科学基金资助项目(81260145) （81260145）
云南省科技厅联合专项基金资助项目(2007C0030R) （2007C0030R）
