临床口腔医学杂志2013，Vol.29Issue(8)：463-466,4.DOI:10.3969/j.issn.1003-1634.2013.08.006
MTHFR基因C677T位点多态性与口腔癌易感性的Meta分析
Association between MTHFR C677T polymorphism and oral cancer risk
摘要
Abstract
Objective:To investigate the association between MTHFR C677T polymorphism and oral cancer risk.Method:The relevant literatures were search.The data of genotype distributions and other information were extracted in the groups of patients and healthy control,Odds ratio (OR) with 95 ％ confidence interval (CI) and publish bias was applied with STATA 11.0 software.Result:Seven published case-control studies including 1318 patients with oral cancer and 1817 controls were selected.Overall,no significant association between MTHFR C677T polymorphism and head and neck cancer risk was found in this meta-analysis (T vs.C:95 ％ CI =0.688 ～ 1.272,P =0.672,Pheterogeneity =0.001 ; TT vs.CC:OR =1.07,95 ％CI=0.638-1.763,P =0.821,Pheterogeneity=0.059; CT vs.CC:95 ％ CI=0.581～1.282,P =0.465,Pheterogeneity=0.002; (CT+TT) vs.CC:95 ％ CI=0.666～ 1.345,P =0.761,Pheterogeneity＜0.001 ;TT vs.(CC+ CT):95 ％ CI=0.709～ 1.247,P=0.669,Pheterogeneity=0.126).In the subgroup analysis ethnicity and study design,significant associations were detected in the models of hospital design with protective tendency.Conclusion:This meta-analysis demonstrates that MTHFR C677T polymorphism may be a protective factor for developing oral cancer.关键词
头颈癌/亚甲四氢叶酸还原酶/多态性/Meta分析Key words
oral cancer/ MTHFR/ polymorphism/ Meta-analysis分类
生物科学引用本文复制引用
许琼莉,牛玉明,胡孝丽,周娟,冷卫东..MTHFR基因C677T位点多态性与口腔癌易感性的Meta分析[J].临床口腔医学杂志,2013,29(8):463-466,4.基金项目
湖北省教育厅重点项目(D20122405)湖北医药学院附属太和医院科研启动基金(2011QD05,2010D22) （D20122405）
