肿瘤预防与治疗2013，Vol.26Issue(4)：208-212,5.DOI:10.3969/j.issn.1674-0904.2013.04.007
头颈部弥漫大B细胞淋巴瘤的免疫组织化学分型分析
Analysis of the Immunohistochemical Subtypes of Diffuse Large B-cell Lymphoma of Head and Neck Region
摘要
Abstract
Objective:To detect the immunohistochemical subtypes of diffuse large B-cell lymphoma of head and neck region,compare the Hans,Choi and Tally algorithm and observe the significances of proteins expression in the three algorithms.Methods:One hundred and three cases of DLBCL of Sichuan Cancer Hospital from May 2010 to October 2012 were studied using immunohistochemistry method for CD10,Bcl-6,MUM1,GCET1,FOXP1 and LMO2.Hans,Choi and Tally subtypes were classified.Results:The results showed that 16 cases(15.53％) were positive for CD10,68 cases(66.02％)for Bcl-6,69 cases(66.99％)for MUM1,21 cases (20.39％)for GCET1,75cases(72.82％)for FOXP1,50 cases(48.54％)for LMO2.In Hans classification,26 cases (25.0％) were GCB and 77cases(75.0％) were ABC subtype.In Choi classification,25 cases (24.0％)were GCB and 78 cases(76.0％) were ABC subtype.In Tally classification,20 cases (19.4％) were GCB and 83 (80.6％) cases were ABC subtype.The expression of CD10,MUMl,GCET1,FOXPl and LMO2 correlated with the classification results(P ＜ 0.05),but the expression of Bcl-6 did not significantly correlate with Hans and Choi classifications.Conclusion:The ABC type is more commonly found than GCB in diffuse large B-cell lymphoma of head and neck region.There is no significant difference among Hans,Choi and Tally classification.The expressions of CD10,MUMl,GCET1,FOXPl and LMO2 correlate with the classification results.关键词
头颈部/弥漫大B细胞淋巴瘤/免疫组织化学分型Key words
Head and Neck region/ Diffuse Large B-cell Lymphoma / Immunohistochemical Subtypes分类
医药卫生引用本文复制引用
李吉满,何先慧,侯俊,万俊峰,汤梅,王影..头颈部弥漫大B细胞淋巴瘤的免疫组织化学分型分析[J].肿瘤预防与治疗,2013,26(4):208-212,5.基金项目
四川省卫生厅科研课题(编号 110269) （编号 110269）
